Propanedioic acid, (acetylamino)(3-methoxy-4-methyl-5-isoxazolyl)methyl-, diethyl ester

Base Information

• Chemical Name: Propanedioic acid, (acetylamino)(3-methoxy-4-methyl-5-isoxazolyl)methyl-, diethyl ester
• CAS No.: 76470-10-5
• Molecular Formula: C15H22 N2 O7
• Molecular Weight: 342.349
• Mol file: 76470-10-5.mol

Synonyms:Propanedioicacid, (acetylamino)[(3-methoxy-4-methyl-5-isoxazolyl)methyl]-, diethyl ester(9CI)

Chemical Property of Propanedioic acid, (acetylamino)(3-methoxy-4-methyl-5-isoxazolyl)methyl-, diethyl ester

Chemical Property:

• PSA: 116.96000
• LogP: 0.92610

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, (acetylamino)(3-methoxy-4-methyl-5-isoxazolyl)methyl-, diethyl ester

There total 1 articles about Propanedioic acid, (acetylamino)(3-methoxy-4-methyl-5-isoxazolyl)methyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-4,5-dimethoxyisoxazole (932-27-4) + 2-acetylaminomalonic acid diethyl ester (1068-90-2) → diethyl acetamido<(3-methoxy-5-methylisoxazol-4-yl)methyl>malonate (75989-23-0) + ethyl α-ethoxycarbonyl-α-acetylamino-3-methoxy-4-methylisoxazole-5-propionate (76470-10-5)

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; sodium; Yield given. Multistep reaction. Yields of byproduct given; 1.) tetrachloromethane, reflux, 2 h, 2.) ethanol, reflux, 4 h;

DOI:10.3891/acta.chem.scand.34b-0235

Reference yield:

ethyl α-ethoxycarbonyl-α-acetylamino-3-methoxy-4-methylisoxazole-5-propionate (76470-10-5) → 4-methylhomoibotenic acid (77006-29-2)

Guidance literature:

With hydrogen bromide; triethylamine; Yield given. Multistep reaction; 1.) 140 deg C, 15 min, 2.) water, ethanol;

DOI:10.3891/acta.chem.scand.34b-0235

upstream raw materials:

3-hydroxy-4,5-dimethoxyisoxazole

2-acetylaminomalonic acid diethyl ester

Downstream raw materials:

4-methylhomoibotenic acid

Refernces