(E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid

Base Information

Chemical Name:(E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid
CAS No.:945965-70-8
Molecular Formula:C₂₅H₂₈N₂O₇
Molecular Weight:468.507
Hs Code.:

Synonyms:(E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid

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Chemical Property of (E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid

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Technology Process of (E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid

There total 8 articles about (E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 945965-69-5
(E)-tert-butyl 6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoate

: 945965-70-8
(E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm070236e

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 945965-70-8
(E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / di-tert-butyl-dicarbonate / 2-methyl-propan-2-ol / 2 h / 20 °C

2: 79 percent / Et₃N / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 12 h / 20 °C

3: 80 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

With di-tert-butyl dicarbonate; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 2: Sonogashira coupling;
DOI:10.1021/jm070236e

Reference yield:

: 73448-14-3
hex-5-ynoic acid tert-butyl ester

: 945965-70-8
(E)-6-(3,7-dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-6-(4-methoxy-3-(methoxycarbamoyl)-5-methylphenyl)hex-5-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / Et₃N / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 12 h / 20 °C

2: 80 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

With triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;
DOI:10.1021/jm070236e