(Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

Base Information

Chemical Name:(Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane
CAS No.:1366416-88-7
Molecular Formula:C₂₃H₂₇FOSi
Molecular Weight:366.551
Hs Code.:

Synonyms:(Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

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Chemical Property of (Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

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Technology Process of (Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

There total 6 articles about (Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: C₁₇H₁₃FO

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1366416-88-7
(Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In acetonitrile; at 0 ℃; for 4h; optical yield given as %de;
DOI:10.1039/c1ob06693e

Reference yield:

: C₁₇H₁₃FO

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1366416-88-7
(Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

: 1366416-80-9
(E)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

Guidance literature:: C₁₇H₁₃FO; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.333333h;

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 0.166667h;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 12h; optical yield given as %de;
DOI:10.1039/c1ob06693e

Reference yield:

: 1043478-99-4
4-cyclopropyl-1-phenylbut-3-yn-1-ol

: 1366416-88-7
(Z)-tert-butyl({[1-(4-fluorophenyl)-4-(4-methylphenyl)but-1-en-3-yn-1-yl]oxy})dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: Jones reagent / acetone / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide / acetonitrile / 4 h / 0 °C

With Jones reagent; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In acetone; acetonitrile;
DOI:10.1039/c1ob06693e