4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

Base Information

Chemical Name:4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile
CAS No.:1541988-28-6
Molecular Formula:C₂₂H₁₅N₅O
Molecular Weight:365.394
Hs Code.:

Synonyms:4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

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Chemical Property of 4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

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Technology Process of 4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

There total 4 articles about 4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1541987-98-7
4-[5-[(4-cyanobenzyl)oxy]-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

: 74-88-4
methyl iodide

: 1541988-28-6
4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

: 1541988-67-3
4-[5-[(4-cyanobenzyl)oxy]-1-methyl-1H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 12h;
DOI:10.1021/jo402599s

Reference yield:

: 874-89-5
4-Cyanobenzyl alcohol

: 1541988-28-6
4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

: 1541988-67-3
4-[5-[(4-cyanobenzyl)oxy]-1-methyl-1H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C

2: iron; ammonium chloride / isopropyl alcohol / 4 h / Reflux

3: sodium hydrogensulfite / N,N-dimethyl-formamide / 12 h / 140 °C / Inert atmosphere

4: potassium carbonate / acetone / 12 h / 20 °C

With iron; sodium hydride; potassium carbonate; ammonium chloride; sodium hydrogensulfite; In N,N-dimethyl-formamide; isopropyl alcohol; acetone; mineral oil;
DOI:10.1021/jo402599s

Reference yield:

: 1541987-83-0
4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile

: 1541988-28-6
4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

: 1541988-67-3
4-[5-[(4-cyanobenzyl)oxy]-1-methyl-1H-imidazo[4,5-b]pyridin-2-yl]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / isopropyl alcohol / 4 h / Reflux

2: sodium hydrogensulfite / N,N-dimethyl-formamide / 12 h / 140 °C / Inert atmosphere

3: potassium carbonate / acetone / 12 h / 20 °C

With iron; potassium carbonate; ammonium chloride; sodium hydrogensulfite; In N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1021/jo402599s