[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid

Base Information

Chemical Name:[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid
CAS No.:1401448-25-6
Molecular Formula:C₂₃H₂₄N₄O₅S₂
Molecular Weight:500.599
Hs Code.:

Synonyms:[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid

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Chemical Property of [1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid

Chemical Property:

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Technology Process of [1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid

There total 18 articles about [1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1401448-25-6
[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

2.1: trifluoroacetic anhydride; tetramethylammonium nitrate / dichloromethane / 20.5 h / -5 - 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Inert atmosphere; Reflux

4.1: hydrogenchloride; water / acetone / 2 h / Reflux

5.1: toluene / 15 h / 85 °C

5.2: 2 h

5.3: 1 h / Reflux

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / Reflux

7.1: trichlorophosphate / chlorobenzene / 100 °C

8.1: 130 °C / Sealed tube; Inert atmosphere

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

10.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

10.2: 0 - 20 °C

11.1: dimethyl sulfoxide / 40 - 44 °C / Inert atmosphere

12.1: formic acid; dihydrogen peroxide / 4 h / 0 - 20 °C

With hydrogenchloride; dmap; lithium aluminium tetrahydride; formic acid; lithium hydroxide monohydrate; water; dihydrogen peroxide; tetramethylammonium nitrate; sodium hydride; triethylamine; trifluoroacetic anhydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; chlorobenzene; acetone; toluene;

Reference yield:

: 1401448-24-5
S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

: 1401448-25-6
[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid

Guidance literature:: With formic acid; dihydrogen peroxide; at 0 - 20 ℃; for 4h;

Reference yield:

: 25391-56-4
3-iodo-5-nitropyridin-2-ylamine

: 1401448-25-6
[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methanesulfonic acid

Guidance literature:: Multi-step reaction with 14 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; 2-ethylbutanamide / 2 h / Inert atmosphere

2.1: copper(l) iodide / N,N-dimethyl-formamide / 2 h / Inert atmosphere

3.1: sodium hydroxide / water; acetone / 0 °C

4.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

5.1: 120 - 130 °C

6.1: Dowtherm A / 250 °C

7.1: sodium hydroxide; water / ethanol / Reflux

8.1: Dowtherm A / 250 °C

9.1: trichlorophosphate / chlorobenzene / 100 °C

10.1: 130 °C / Sealed tube; Inert atmosphere

11.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

12.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

12.2: 0 - 20 °C

13.1: dimethyl sulfoxide / 40 - 44 °C / Inert atmosphere

14.1: formic acid; dihydrogen peroxide / 4 h / 0 - 20 °C

With lithium aluminium tetrahydride; formic acid; Dowtherm A; water; hydrogen; dihydrogen peroxide; sodium hydride; triethylamine; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; 2-ethylbutanamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; chlorobenzene; acetone;