S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

Base Information

Chemical Name:S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate
CAS No.:1401448-24-5
Molecular Formula:C₂₅H₂₆N₄O₃S₂
Molecular Weight:494.638
Hs Code.:

Synonyms:S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

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Chemical Property of S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

Chemical Property:

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Technology Process of S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

There total 17 articles about S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1401448-24-5
S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

Guidance literature:: Multi-step reaction with 11 steps

1.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

2.1: trifluoroacetic anhydride; tetramethylammonium nitrate / dichloromethane / 20.5 h / -5 - 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Inert atmosphere; Reflux

4.1: hydrogenchloride; water / acetone / 2 h / Reflux

5.1: toluene / 15 h / 85 °C

5.2: 2 h

5.3: 1 h / Reflux

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / Reflux

7.1: trichlorophosphate / chlorobenzene / 100 °C

8.1: 130 °C / Sealed tube; Inert atmosphere

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

10.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

10.2: 0 - 20 °C

11.1: dimethyl sulfoxide / 40 - 44 °C / Inert atmosphere

With hydrogenchloride; dmap; lithium aluminium tetrahydride; lithium hydroxide monohydrate; water; tetramethylammonium nitrate; sodium hydride; triethylamine; trifluoroacetic anhydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; chlorobenzene; acetone; toluene;

Reference yield:

: 1401448-23-4
[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl4-methylbenzenesulfonate

: 10387-40-3
potassium thioacetate

: 1401448-24-5
S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

Guidance literature:: In dimethyl sulfoxide; at 40 - 44 ℃; Inert atmosphere;

Reference yield:

: 744209-63-0
1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine

: 1401448-24-5
S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

Guidance literature:: Multi-step reaction with 10 steps

1.1: trifluoroacetic anhydride; tetramethylammonium nitrate / dichloromethane / 20.5 h / -5 - 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Inert atmosphere; Reflux

3.1: hydrogenchloride; water / acetone / 2 h / Reflux

4.1: toluene / 15 h / 85 °C

4.2: 2 h

4.3: 1 h / Reflux

5.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / Reflux

6.1: trichlorophosphate / chlorobenzene / 100 °C

7.1: 130 °C / Sealed tube; Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

9.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

9.2: 0 - 20 °C

10.1: dimethyl sulfoxide / 40 - 44 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; water; tetramethylammonium nitrate; sodium hydride; trifluoroacetic anhydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; chlorobenzene; acetone; toluene;