Technology Process of N1-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-ψ-uridine
There total 7 articles about N1-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-ψ-uridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 92 percent / BSA / CH2Cl2 / 1.) room temperature, 1 h, 2.) reflux, 5 d
2: 90 percent / NH3 / methanol / 24 h / Ambient temperature
3: 94 percent / pyridine / 1.) 0 deg C, 1 h, 2.) room temperature, 4 h
4: 82 percent / dimethylformamide / 4.5 h / Ambient temperature
5: 82.2 percent / n-Bu3SnH, AIBN / toluene / 1 h / Heating
6: 85 percent / n-Bu4NF / tetrahydrofuran / 1 h / Ambient temperature
7: 84.5 percent / Et3N / pyridine / 4 h / Ambient temperature
With
benzenesulfonamide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; ammonia; tri-n-butyl-tin hydride; triethylamine;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1080/15257779508010690
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82 percent / dimethylformamide / 4.5 h / Ambient temperature
2: 82.2 percent / n-Bu3SnH, AIBN / toluene / 1 h / Heating
3: 85 percent / n-Bu4NF / tetrahydrofuran / 1 h / Ambient temperature
4: 84.5 percent / Et3N / pyridine / 4 h / Ambient temperature
With
2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; triethylamine;
In
tetrahydrofuran; pyridine; N,N-dimethyl-formamide; toluene;
DOI:10.1080/15257779508010690
