65358-15-8

Upstream product

• 80545-48-8 N1-methyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-ψ-uridine 
• 1445-07-4 pseudouridine 
• 1166395-06-7 C₁₀H₁₂N₂O₅ 
• 78064-62-7 1-Methyl-2',3'-O-(thionocarbonyl)-5'-O-tritylpseudouridine 
• 78064-61-6 1-Methyl-5'-O-tritylpseudouridine 
• 97430-85-8 3'-O-acetyl-2'-O-triflyl-4,5'-anhydro-1-methyl-ψ-uridine 
• 97416-17-6 1-methyl-5-(2',3'-O-carbonyl-5'-O-mesyl-β-D-ribofuranosyl)uracil 
• 97416-15-4 1-methyl-2',3'-O-isopropylidene-5'-O-mesyl-ψ-uridine 
• 97416-16-5 1-methyl-5'-O-mesyl-ψ-uridine 
• 97416-14-3 1-methyl-2',3'-O-isopropylidene-ψ-uridine 
• 97416-21-2 Acetic acid (1S,10R,11R,12R)-12-chloro-4-methyl-5-oxo-8,13-dioxa-4,6-diaza-tricyclo[8.2.1.0^2,7]trideca-2,6-dien-11-yl ester 
• 97416-18-7 4,5'-anhydro-1-methyl-5-(2',3'-O-carbonyl-β-D-ribofuranosyl)uracil 
• 97416-19-8 4,5'-anhydro-1-methyl-5-(β-D-ribofuranosyl)uracil 
• 61289-19-8 N1-methyl-2',3',5'-tri-O-acetyl-ψ-uridine 

Downstream Products

• 136804-01-8 N1-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-ψ-uridine 
• 127517-38-8 3'-azido-2',3'-dideoxy-1-methylpseudouridine 
• 127517-29-7 3',4-anhydro-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)-1-methyluracil 
• 127517-34-4 1-methyl-5-(2-deoxy-5-O-trityl-β-D-glycero-pentofuranos-3-ulosyl)uracil 
• 127517-37-7 3'-azido-2',3'-dideoxy-5'-O-trityl-1-methylpseudouridine 
• 127517-35-5 1-methyl-5-(2-deoxy-5-O-trityl-β-D-threo-pentofuranosyl)uracil 
• 127517-36-6 1-methyl-5-(2-deoxy-3-O-mesyl-5-O-trityl-β-D-threo-pentofuranosyl)uracil 
• 127517-28-6 1-methyl-2'-deoxy-3'-O-mesyl-5'-O-tritylpseudouridine 
• 78064-64-9 1-methyl-2'-deoxy-5'-O-tritylpseudouridine 

Relevant academic research and scientific papers

2′-Deoxy-1-methylpseudocytidine, a stable analog of 2′-deoxy-5-methylisocytidine

2′-Deoxy-5-methylisocytidine is widely used in assays to personalize the care of patients infected with HIV, hepatitis C, and other infectious agents. However, oligonucleotides that incorporate 2′-deoxy-5-methylisocytidine are expensive, because of its in

A practical synthesis of N1-methyl-2'-deoxy-ψ-uridine (ψ-thymidine) and its incorporation into G-rich triple helix forming oligonucleotides

A convenient synthesis of N1-methyl-2'-deoxy-ψ-uridine (ψ-thymidine, ψT, 7a) has been accomplished in good yield. The structural conformation of 7a was derived by 2D NMR and 1D NOE experiments. The nucleoside 7a has been incorporated into G-rich triplex f

Nucleosides. 121. Improved and General Synthesis of 2'-Deoxy C-Nucleosides. Synthesis of 5-(2-Deoxy-β-D-erythro-pentofuranosyl)uracil, -1-methyluracil, -1,3-dimethyluracil, and -isocytosine

5-(2-Deoxy-β-D-erythro-pentofuranosyl)-1,3-dimethyluracil (6a), -1-methyluracil (6b), -uracil (6c), and -isocytosine (6d) were synthesized.Compounds 6b-d are C-nucleoside isosteres of thymidine, 2'-deoxyuridine, and 2'-deoxycytidine, respectively. 1,3-Dimethylpseudouridine (1a), 1-methylpseudouridine (1b), pseudouridine (1c), and pseudoisocytidine (1d) were treated with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane in pyridine to afford the corresponding 3',5'-tetraisopropyldisiloxanyl derivatives 2 which were converted into the respective 2'-O- C-nucleosides 3.Compounds 3a,b were converted directly into the corresponding 2'-deoxy β-C-nuleosides 5a,b exclusively by reduction with n-Bu3SnH.For the synthesis of 2'-deoxy β-C-nucleosides 5c,d, the intermediates 3c,d were trimethylsilylated prior to n-Bu3SnH treatment.Deprotection of 5a-d was effected by treatment with n-Bu4NF, and the corresponding free 2'-deoxy β-C-nucleosides 6a-d were obtained in good yields.