methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1335116-71-6
Molecular Formula:C₃₂H₃₈F₃N₃O₆S
Molecular Weight:649.731
Hs Code.:

methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Synonyms:methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Chemical Property of methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

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Technology Process of methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 9 articles about methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1335116-70-5
methyl 3-(bromomethyl)-7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 53617-35-9
4-(piperidin-4-yl)morpholine

: 1335116-71-6
methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: In acetonitrile; for 3h;

Reference yield:

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 1335116-71-6
methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / Reflux

1.2: 20 °C / Reflux

2.1: sodium hydride / dimethyl sulfoxide / 0.33 h

2.2: 2 h / 100 °C

2.3: 2 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

4.1: hydrogen bromide; acetic acid / 120 h / Reflux

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

5.2: 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

7.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

8.1: acetonitrile / 3 h

With N-Bromosuccinimide; oxalyl dichloride; hydrogen bromide; sodium hydride; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 64465-53-8
4-fluoro-3-methoxyaniline

: 1335116-71-6
methyl 7-[(1-methylethyl)oxy]-6-(methylsulfonyl)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / Reflux

1.2: 20 °C / Reflux

2.1: sodium hydride / dimethyl sulfoxide / 0.33 h

2.2: 2 h / 100 °C

2.3: 2 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

4.1: hydrogen bromide; acetic acid / 120 h / Reflux

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

5.2: 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

7.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

8.1: acetonitrile / 3 h

With N-Bromosuccinimide; oxalyl dichloride; hydrogen bromide; sodium hydride; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;