4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

Base Information

Chemical Name:4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene
CAS No.:246022-83-3
Molecular Formula:C₁₁H₁₂BrClO
Molecular Weight:275.573
Hs Code.:

Synonyms:4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

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Chemical Property of 4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

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Technology Process of 4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

There total 1 articles about 4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 553-94-6
4-bromo-m-xylene

: 625-36-5
2-chloropropionyl chloride

: 246022-83-3
4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

Guidance literature:: 2-chloropropionyl chloride; With aluminum (III) chloride; In dichloromethane; for 0.25h; Schlenk technique; Inert atmosphere;

4-bromo-m-xylene; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 246022-83-3
4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

: 186145-04-0
5,8-dimethyl-6-(phenylsulfanyl)isoquinolin-7-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 40.3 g / H₂SO₄ / H₂O / 1 h / 80 °C

2.1: 66 percent / HNO₃ / H₂O / 0.08 h / -20 °C

3.1: 99 percent / NaBH₄ / methanol / 0.17 h / 0 °C

4.1: 86 percent / TsOH / benzene / 16 h / Heating

5.1: O₃ / CH₂Cl₂; methanol / -78 °C

5.2: Me₂S; NaHCO₃ / CH₂Cl₂; methanol / 4 h / 20 °C

5.3: 89 percent / NH₃ / CH₂Cl₂; methanol; H₂O / 16 h

6.1: 94 percent / NaOMe / dimethylformamide / 6 h / Heating

7.1: hydrazine monohydrate; Raney nickel / H₂O; ethanol / 2 h / Heating

With sodium tetrahydroborate; sulfuric acid; nitric acid; sodium methylate; nickel; toluene-4-sulfonic acid; ozone; hydrazine hydrate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(02)00587-2

Reference yield:

: 246022-83-3
4-bromo-1-(3'-chloro-1'-oxopropyl)-2,5-dimethylbenzene

: 5-methyl-4-(phenylsulfanyl)-3H-pyrazolo[3,4-h]isoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: 40.3 g / H₂SO₄ / H₂O / 1 h / 80 °C

2.1: 66 percent / HNO₃ / H₂O / 0.08 h / -20 °C

3.1: 99 percent / NaBH₄ / methanol / 0.17 h / 0 °C

4.1: 86 percent / TsOH / benzene / 16 h / Heating

5.1: O₃ / CH₂Cl₂; methanol / -78 °C

5.2: Me₂S; NaHCO₃ / CH₂Cl₂; methanol / 4 h / 20 °C

5.3: 89 percent / NH₃ / CH₂Cl₂; methanol; H₂O / 16 h

6.1: 94 percent / NaOMe / dimethylformamide / 6 h / Heating

7.1: hydrazine monohydrate; Raney nickel / H₂O; ethanol / 2 h / Heating

8.1: 41 percent / HOAc; NaNO₂ / H₂O / 0 - 20 °C

With sodium tetrahydroborate; sulfuric acid; nitric acid; sodium methylate; nickel; toluene-4-sulfonic acid; ozone; hydrazine hydrate; acetic acid; sodium nitrite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(02)00587-2