5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester

Base Information

• Chemical Name: 5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester
• CAS No.: 370097-81-7
• Molecular Formula: C₂₆H₃₆O₆
• Molecular Weight: 444.568
• Mol file: 370097-81-7.mol

Synonyms:5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester

Chemical Property of 5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester

There total 4 articles about 5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

2,2-bis-[3-(4-methoxy-benzyloxy)-propyl]-malonic acid diethyl ester (370097-57-7) → 5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester (370097-81-7)

Guidance literature:

With water; lithium chloride; In dimethyl sulfoxide; at 140 ℃; for 72h;

DOI:10.1021/jo0101508

Reference yield:

O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → 5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester (370097-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 10-camphorsulfonic acid / cyclohexane; CH₂Cl₂ / 12 h / 20 °C

2: 64 percent / NaH; Bu₄NI / tetrahydrofuran / 48 h / Heating

3: 38 percent / LiCl; H₂O / dimethylsulfoxide / 72 h / 140 °C

With (1S)-10-camphorsulfonic acid; water; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium chloride; In tetrahydrofuran; dichloromethane; cyclohexane; dimethyl sulfoxide;

DOI:10.1021/jo0101508

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → 5-(4-methoxy-benzyloxy)-2-[3-(4-methoxy-benzyloxy)-propyl]-pentanoic acid ethyl ester (370097-81-7)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / diethyl ether / 4 h / 0 - 20 °C

2: 10-camphorsulfonic acid / cyclohexane; CH₂Cl₂ / 12 h / 20 °C

3: 64 percent / NaH; Bu₄NI / tetrahydrofuran / 48 h / Heating

4: 38 percent / LiCl; H₂O / dimethylsulfoxide / 72 h / 140 °C

With (1S)-10-camphorsulfonic acid; water; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium chloride; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; dimethyl sulfoxide;

DOI:10.1021/jo0101508

upstream raw materials:

2,2-bis-[3-(4-methoxy-benzyloxy)-propyl]-malonic acid diethyl ester

O-(4-methoxybenzyl)-trichloroacetimidate

4-Methoxybenzyl alcohol

1-[(3-bromopropoxy)methyl]-4-methoxybenzene