(E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

Base Information

Chemical Name:(E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide
CAS No.:1384861-68-0
Molecular Formula:C₂₃H₂₁N₅O₃
Molecular Weight:415.451
Hs Code.:

Synonyms:(E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

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Technology Process of (E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

There total 8 articles about (E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.6%

: 1384861-61-3
(E)-N-(3-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

: 74-88-4
methyl iodide

: 1384861-68-0
(E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;
DOI:10.1248/cpb.60.385

Reference yield:

: C₂₂H₂₁N₅O₄

: 1384861-68-0
(E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 8 h / 90 - 105 °C

1.2: 0 °C / pH 4

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.60.385

Reference yield:

: 6632-68-4
6-amino-1,3-dimethyl-5-nitroso-1H-pyrimidine-2,4-dione

: 1384861-68-0
(E)-N-(3-(1,3,7-trimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)cinnamamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / 0.5 h / 70 °C

1.2: 50 °C

2.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane; water / 8 h / pH 5

3.1: sodium hydroxide / 1,4-dioxane; water / 8 h / 90 - 105 °C

3.2: 0 °C / pH 4

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With hydrogenchloride; ammonium hydroxide; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.60.385