2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

Base Information

Chemical Name:2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid
CAS No.:1404070-18-3
Molecular Formula:C₂₇H₂₇F₆NO₂
Molecular Weight:511.507
Hs Code.:

Synonyms:2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

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Chemical Property of 2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

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Technology Process of 2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

There total 2 articles about 2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404070-33-2
C₂₈H₂₉F₆NO₂

: 1404070-18-3
2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.08.034 DOI:10.1016/j.bmc.2012.08.034

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 884602-78-2
(+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

: 598-23-2
3-methyl-but-1-yne

: 1404070-18-3
2-((2S,4R)-1-((S)-1-(4-trifluoromethylphenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper(I) bromide / toluene / 24 h / 90 °C / Inert atmosphere; Glovebox; Molecular sieve

2: lithium hydroxide monohydrate / methanol; tetrahydrofuran; water / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; copper(I) bromide; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1016/j.bmc.2012.08.034 DOI:10.1016/j.bmc.2012.08.034