3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one

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Chemical Name:3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one
CAS No.:877140-79-9
Molecular Formula:C₂₄H₁₇F₂N₃O₄S
Molecular Weight:481.479
Hs Code.:

Synonyms:3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one

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Chemical Property of 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one

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Technology Process of 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one

There total 2 articles about 3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877140-80-2
N-{3-[6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-quinolin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-7-yl}-acetamide

: 877140-79-9
3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one

Guidance literature:: N-{3-[6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-quinolin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-7-yl}-acetamide; With sodium hydroxide; ethanol; water; Heating / reflux;

With hydrogenchloride; In water;

Reference yield:

: 749865-72-3
6-fluoro-1-(4-fluoro-benzyl)-1H-benzo[d][1,3]oxazine-2,4-dione

: C₁₂H₁₄N₂O₄S

: 877140-79-9
3-(7-amino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-6-fluoro-1-(4-fluoro-benzyl)-4-hydroxy-1H-quinolin-2-one

Guidance literature:: C₁₂H₁₄N₂O₄S; With potassium tert-butylate; In tetrahydrofuran;

6-fluoro-1-(4-fluoro-benzyl)-1H-benzo[d][1,3]oxazine-2,4-dione; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2009.05.004