N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

Base Information

Chemical Name:N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide
CAS No.:1356629-00-9
Molecular Formula:C₃₃H₃₅N₅O₄
Molecular Weight:565.672
Hs Code.:

Synonyms:N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

Suppliers and Price of N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

There total 7 articles about N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353977-72-6,1158365-82-2
4-amino-1-(4-cyanobenzyl)piperidine dihydrochloride

: 1356633-46-9
6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinic acid

: 1356629-00-9
N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: 6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)-N-(piperidin-4-yl)nicotinamide

: 17201-43-3
4-cyanobenzyl bromide

: 1356629-00-9
N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2018.07.006

Reference yield:

: 25519-82-8
(4-methoxy-phenyl)-piperidin-4-yl-methanone hydrochloride

: 1356629-00-9
N-(1-(4-cyanobenzyl)piperidin-4-yl)-6-(4-(4-methoxybenzoyl)piperidine-1-carbonyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 0.33 h / 20 °C

3: triethylamine; HATU / N,N-dimethyl-formamide / 6 h / 20 °C

With lithium hydroxide monohydrate; water; triethylamine; HATU; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;