3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol

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Chemical Name:3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol
CAS No.:209404-32-0
Molecular Formula:C₃₀H₄₀O₅SSi
Molecular Weight:540.796
Hs Code.:

Synonyms:3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol

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Chemical Property of 3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol

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Technology Process of 3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol

There total 5 articles about 3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 209404-26-2
methyl 3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propanoate

: 209404-32-0
3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 10 ℃; for 0.166667h;
DOI:10.1016/S0040-4020(01)00679-2

Reference yield:

: 209404-16-0
methyl (2-benzyloxy-4-methoxyphenyl)acetate

: 209404-32-0
3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pt / acetone / Ambient temperature

2: imidazole / dimethylformamide / Ambient temperature

3: 1.) LDA / 1.) Et₂O, -78 deg C; 2.) Et₂O, -78 deg C to 0 deg C

4: 81 percent / SnCl₄ / CH₂Cl₂ / 0 °C

5: 78 percent / LiAlH₄ / diethyl ether / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; tin(IV) chloride; lithium diisopropyl amide; platinum; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(98)00607-8

Reference yield:

: 212688-07-8
methyl (2-hydroxy-4-methoxyphenyl)acetate

: 209404-32-0
3-benzylsulfanyl-2-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-3-(2''-hydroxy-4''-methoxyphenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / Ambient temperature

2: 1.) LDA / 1.) Et₂O, -78 deg C; 2.) Et₂O, -78 deg C to 0 deg C

3: 81 percent / SnCl₄ / CH₂Cl₂ / 0 °C

4: 78 percent / LiAlH₄ / diethyl ether / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; tin(IV) chloride; lithium diisopropyl amide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00607-8