3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile

Base Information

Chemical Name:3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile
CAS No.:1167416-12-7
Molecular Formula:C₁₉H₁₆ClN₃O₂
Molecular Weight:353.808
Hs Code.:

Synonyms:3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile

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Chemical Property of 3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile

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Technology Process of 3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile

There total 3 articles about 3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1167416-11-6
3-cyano-N-hydroxy-2-methylbenzenecarboximidamide

: 213598-06-2
methyl 3-chloro-4-isopropoxybenzoate

: 1167416-12-7
3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile

Guidance literature:: 3-cyano-N-hydroxy-2-methylbenzenecarboximidamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl 3-chloro-4-isopropoxybenzoate; In tetrahydrofuran; at 20 ℃; for 20h; Heating / reflux;

Reference yield: 90.0%

3-cyano-N-hydroxy-2-methylbenzenecarboximidamide: 1167416-11-6
3-cyano-N-hydroxy-2-methylbenzenecarboximidamide

: 213598-06-2
methyl 3-chloro-4-isopropoxybenzoate

: 1167416-12-7
3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile

Guidance literature:: 3-cyano-N-hydroxy-2-methylbenzenecarboximidamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

methyl 3-chloro-4-isopropoxybenzoate; In tetrahydrofuran; mineral oil; at 20 ℃; Reflux;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1167416-12-7
3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 0.75 h / Inert atmosphere; Reflux

With sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm5010336