2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione

Base Information

• Chemical Name: 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione
• CAS No.: 942613-38-9
• Molecular Formula: C₁₉H₁₇N₃O₂
• Molecular Weight: 319.363
• Mol file: 942613-38-9.mol

Synonyms:2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione

Chemical Property of 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione

There total 6 articles about 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethylenediamine (107-15-3,85404-18-8) → 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione (942613-38-9)

Guidance literature:

4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzonitrile; With hydrogenchloride; ethanol; at 0 - 8 ℃;

ethylenediamine; In ethanol; at 20 ℃;

Reference yield: 62.0%

4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzonitrile (308846-03-9) + ethylenediamine (107-15-3,85404-18-8) → 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione (942613-38-9)

Guidance literature:

4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzonitrile; With hydrogenchloride; ethanol; at 0 - 8 ℃;

ethylenediamine; In ethanol; at 20 ℃;

Reference yield:

phthalimide (136918-14-4,85-41-6) → 2-{2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-ethyl}-isoindole-1,3-dione (942613-38-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; diethylazodicarboxylate / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.065

upstream raw materials:

ethylenediamine

4-[2-(1,3-dioxoisoindolin-2-yl)ethyl]benzonitrile

phthalimide

ethyl 4-(2-phthalimidoethyl)benzoate

Downstream raw materials:

2-[4-(4,5-dihydro-1H-imidazol-2-yl)-phenyl]-ethylamine

C₃₅H₃₆N₄O₃S

C₂₈H₂₈Cl₂N₄O₃S

C₂₈H₂₈Cl₂N₄O₃S