3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane

Base Information

Chemical Name:3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane
CAS No.:736985-63-0
Molecular Formula:C₂₀H₃₆O₄Si
Molecular Weight:368.589
Hs Code.:

Synonyms:3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane

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Chemical Property of 3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane

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Technology Process of 3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane

There total 7 articles about 3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 122-51-0
orthoformic acid triethyl ester

: 736985-53-8
3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-propionaldehyde

: 736985-63-0
3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane

Guidance literature:: With camphor-10-sulfonic acid; In methanol; at 45 ℃; for 0.5h;
DOI:10.1002/chem.200305629

Reference yield:

: 13391-35-0
allyl (4-methoxyphenyl) ether

: 736985-63-0
3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / 0.75 h / 240 °C

2.1: 96 percent / imidazole / dimethylformamide / 1 h / 20 °C

3.1: BH₃*THF / tetrahydrofuran / 2.17 h / 0 - 20 °C

3.2: 89 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 1.25 h / 0 - 20 °C

4.1: 94 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 20 °C

5.1: 76 percent / (+/-)-camphorsulfonic acid / methanol / 0.5 h / 45 °C

With 1H-imidazole; borane-THF; oxalyl dichloride; camphor-10-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Claisen rearrangement;
DOI:10.1002/chem.200305629

Reference yield:

: 584-82-7
2-allyl-4-methoxyphenol

: 736985-63-0
3-[(2-tert-butyldimethylsilanyloxy)-5-methoxyphenyl]-1,1-diethoxypropane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / imidazole / dimethylformamide / 1 h / 20 °C

2.1: BH₃*THF / tetrahydrofuran / 2.17 h / 0 - 20 °C

2.2: 89 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 1.25 h / 0 - 20 °C

3.1: 94 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 20 °C

4.1: 76 percent / (+/-)-camphorsulfonic acid / methanol / 0.5 h / 45 °C

With 1H-imidazole; borane-THF; oxalyl dichloride; camphor-10-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200305629