methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate

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Chemical Name:methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate
CAS No.:1048330-21-7
Molecular Formula:C₃₄H₄₁ClN₂O₆
Molecular Weight:609.162
Hs Code.:

Synonyms:methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate

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Chemical Property of methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate

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Technology Process of methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate

There total 11 articles about methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 603124-58-9
methyl 3-amino-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate

: 107-08-4
1-iodo-propane

: 1048330-21-7
methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 22h;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 1048330-21-7
methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6: iron; ammonium chloride / ethanol; water / 2 h / Reflux

7: potassium carbonate / N,N-dimethyl-formamide / 22 h / 20 - 80 °C

With palladium 10% on activated carbon; hydrogen; copper diacetate; boron tribromide; iron; potassium carbonate; ammonium chloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm800222k

Reference yield:

: 603123-22-4
methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-nitrobenzoate

: 1048330-21-7
methyl 3-{[(7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}-5-(propylamino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / ethanol; water / 2 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 22 h / 20 - 80 °C

With iron; potassium carbonate; ammonium chloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm800222k