tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate

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Chemical Name:tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate
CAS No.:1429503-88-7
Molecular Formula:C₂₈H₃₀F₂N₆O₃
Molecular Weight:536.581
Hs Code.:

Synonyms:tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate

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Chemical Property of tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate

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Technology Process of tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate

There total 3 articles about tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1429504-08-4
C₂₁H₂₅N₃O₃

: 622372-76-3
3,4-difluorobenzyl azide

: 1429503-88-7
tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.07.034

Reference yield:

: 680227-80-9
[(S)-2-((S)-2-Cyano-pyrrolidin-1-yl)-1-(4-iodo-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 1429503-88-7
tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol / 3 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; triethylamine; In tetrahydrofuran; ethanol; 1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2013.07.034

Reference yield:

: 1429503-68-3
C₂₄H₃₃N₃O₃Si

: 1429503-88-7
tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-3-[4-(1-(3,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)phenyl]-1-oxopropan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol / 3 h / 20 °C

With copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2013.07.034