(+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

Base Information

Chemical Name:(+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline
CAS No.:1050527-01-9
Molecular Formula:C₂₇H₂₆Cl₂N₄
Molecular Weight:477.436
Hs Code.:

Synonyms:(+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

Suppliers and Price of (+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

There total 4 articles about (+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1392422-14-8
N-((4-chlorophenyl)(4-(1-tert-butoxycarbonylpiperazin-4-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline

: 1050527-01-9
(+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

Guidance literature:: With acetyl chloride; In methanol; at 25 ℃; for 2h;
DOI:10.1021/jm300802s

Reference yield: 68.0%

: 1050527-01-9
(+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

Guidance literature:

Reference yield:

: 91457-11-3
4-bromomethyl-4'-chlorobenzophenone

: 1050527-01-9
(+/-)-7-chloro-N-{(4-chlorophenyl)[4-(piperazin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile / 1 h / 0 °C

2.1: sodium tetrahydroborate / ethanol / 1 h / 0 °C

3.1: thionyl chloride / dichloromethane / 4.33 h / 0 - 45 °C

3.2: 6 h / 0 - 80 °C

4.1: acetyl chloride / methanol / 2 h / 25 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; acetyl chloride; In methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm300802s