(E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

Base Information

• Chemical Name: (E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene
• CAS No.: 1104449-20-8
• Molecular Formula: C₁₆H₁₃F₃O
• Molecular Weight: 278.274
• Mol file: 1104449-20-8.mol

Synonyms:(E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

Chemical Property of (E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene

There total 5 articles about (E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[4-(benzyloxy)phenyl]boronic acid (146631-00-7) + trans-1-chloro-3,3,3-trifluoropropene (102687-65-0) → (E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene (1104449-20-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In water; N,N-dimethyl-formamide; at 90 ℃; for 0.333333h; Inert atmosphere; Sealed tube;

Reference yield: 80.0%

4-benzyloxycinnamic acid (6272-45-3,227105-11-5) + Langlois reagent (2926-29-6) → (E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene (1104449-20-8)

Guidance literature:

With potassium tert-butylate; tert-butylammonium hexafluorophosphate(V); In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 3h; regioselective reaction; Electrolysis;

DOI:10.1021/acs.joc.9b00766

Reference yield: 74.0%

(E)-1-bromo-3,3,3-trifluoroprop-1-ene (149597-47-7) + [4-(benzyloxy)phenyl]boronic acid (146631-00-7) → (E)-1-(benzyloxy)-4-(3,3,3-trifluoroprop-1-en-1-yl)benzene (1104449-20-8)

Guidance literature:

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 90 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

1,1,1-trifluoropropylene

4-(4-benzyloxyphenyl) iodide

(E)-1-bromo-3,3,3-trifluoroprop-1-ene

[4-(benzyloxy)phenyl]boronic acid

Downstream raw materials:

4-(3,3,3-trifluoropropyl)phenol