5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene
• CAS No.: 172938-00-0
• Molecular Formula: C₂₆H₂₈O₂Si
• Molecular Weight: 400.593
• Mol file: 172938-00-0.mol

Synonyms:5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene

Chemical Property of 5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene

There total 1 articles about 5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-Hydroxy-1-tetralone (28315-93-7) + tert-butylchlorodiphenylsilane (58479-61-1) → 5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene (172938-00-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 10h;

DOI:10.1016/j.bmcl.2015.01.024

Reference yield:

5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene (172938-00-0) + 2-(4,5-diphenyloxazol-2-yl)ethylamine (33162-03-7) → 1-[2-(4,5-diphenyloxazol-2-yl)ethylamino]-1,2,3,4-tetrahydro-5-(t-butyldiphenylsilyloxy)naphthalene

Guidance literature:

With sodium tetrahydroborate; toluene-4-sulfonic acid; In methanol; toluene;

Reference yield:

5-(t-butyldiphenylsilyloxy)-1-oxo-1,2,3,4-tetrahydronaphthalene (172938-00-0) + triethyl phosphate (78-40-0) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2,83329-50-4) → 5-t-butyldiphenylsilyloxy-1-ethoxycarbonylmethyl-3,4-dihydronaphthalene

Guidance literature:

With NaH; In 1,2-dimethoxyethane; water; ethyl acetate; toluene;

upstream raw materials:

5-Hydroxy-1-tetralone

tert-butylchlorodiphenylsilane

Downstream raw materials:

(1S)-1-hydroxy-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

1-hydroxy-1-ethoxycarbonylmethyl-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene