trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione

Base Information

• Chemical Name: trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione
• CAS No.: 139938-34-4
• Molecular Formula: C₂₁H₂₀BrNS₂
• Molecular Weight: 430.433
• Mol file: 139938-34-4.mol

Synonyms:trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione

Chemical Property of trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione

There total 3 articles about trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(α-(N-benzyl-thiocarbamoylthio)-4-bromobenzyl)-cyclohexan-1-one (139938-24-2) → trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione (139938-34-4)

Guidance literature:

With sulfuric acid; acetic anhydride; at 20 ℃; for 0.5h;

DOI:10.1007/BF00811113

Reference yield:

(E)-2-(4-bromobenzylidene)cyclohexan-1-one (111729-78-3) → trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione (139938-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / 6.5N aq. HCl / methanol; acetone / 4 h / -5 °C

2: 87 percent / Ac₂O, conc. H₂SO₄ / 0.5 h / 20 °C

With hydrogenchloride; sulfuric acid; acetic anhydride; In methanol; acetone;

DOI:10.1007/BF00811113

Reference yield:

N-benzyl-dithiocarbamic acid ammonium salt (41270-27-3) → trans-N-benzyl-4-(4-bromophenyl)-4a,5,6,7-tetrahydro-4H-3,1-benzothiazine-2(1H)-thione (139938-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / 6.5N aq. HCl / methanol; acetone / 4 h / -5 °C

2: 87 percent / Ac₂O, conc. H₂SO₄ / 0.5 h / 20 °C

With hydrogenchloride; sulfuric acid; acetic anhydride; In methanol; acetone;

DOI:10.1007/BF00811113

upstream raw materials:

2-(α-(N-benzyl-thiocarbamoylthio)-4-bromobenzyl)-cyclohexan-1-one

(E)-2-(4-bromobenzylidene)cyclohexan-1-one

N-benzyl-dithiocarbamic acid ammonium salt