2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

Base Information

• Chemical Name: 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene
• CAS No.: 1244030-72-5
• Molecular Formula: C₂₁H₁₇ClN₄OS
• Molecular Weight: 408.911
• Mol file: 1244030-72-5.mol

Synonyms:2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

Chemical Property of 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene

There total 5 articles about 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

[2-(2-chlorophenyl)-1,3-thiazol-4-yl]carboxyaldehyde (639517-84-3) + malononitrile (109-77-3) + 3-Dimethylaminophenol (99-07-0) → 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene (1244030-72-5)

Guidance literature:

With piperidine; In ethanol; at 35 ℃; for 12h;

DOI:10.1002/ardp.200900198

Reference yield:

4-chloromethyl-2-(2-chloro-phenyl)-thiazole (588676-51-1) → 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene (1244030-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; water / Reflux

2: manganese(IV) oxide / chloroform / 12 h / 20 °C

3: piperidine / ethanol / 12 h / 35 °C

With piperidine; manganese(IV) oxide; sulfuric acid; water; In ethanol; chloroform;

DOI:10.1002/ardp.200900198

Reference yield:

2-(2-chlorophenyl)-4-hydroxymethylthiazole (639517-86-5) → 2-amino-3-cyano-4-[2-(2-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene (1244030-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / chloroform / 12 h / 20 °C

2: piperidine / ethanol / 12 h / 35 °C

With piperidine; manganese(IV) oxide; In ethanol; chloroform;

DOI:10.1002/ardp.200900198

upstream raw materials:

[2-(2-chlorophenyl)-1,3-thiazol-4-yl]carboxyaldehyde

malononitrile

3-Dimethylaminophenol

4-chloromethyl-2-(2-chloro-phenyl)-thiazole