(E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

Base Information

Chemical Name:(E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol
CAS No.:218435-04-2
Molecular Formula:C₂₅H₃₄O₅S
Molecular Weight:446.608
Hs Code.:

Synonyms:(E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

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Chemical Property of (E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

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Technology Process of (E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

There total 5 articles about (E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 218434-99-2
(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

: 218435-04-2
(E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 133094-78-7
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

: 218435-04-2
(E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / Me₃Al / hexane; benzene / 1 h / Ambient temperature

2: CBr₄, PPh₃ / acetonitrile / 2 h / Ambient temperature

3: DBU / benzene / 48 h / Heating

4: 65 percent / di-isobutylaluminium hydride / hexane; CH₂Cl₂ / 2 h / -78 °C

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

6: TBAF / tetrahydrofuran / 3 h / Ambient temperature

With n-butyllithium; diisobutylaluminum hydride; carbon tetrabromide; tetrabutyl ammonium fluoride; trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 218434-96-9
(R)-4-Bromo-2-(tert-butyl-dimethyl-silanyloxy)-N-methoxy-3,3,N-trimethyl-butyramide

: 218435-04-2
(E)-(4R,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

Guidance literature:: Multi-step reaction with 4 steps

1: DBU / benzene / 48 h / Heating

2: 65 percent / di-isobutylaluminium hydride / hexane; CH₂Cl₂ / 2 h / -78 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

4: TBAF / tetrahydrofuran / 3 h / Ambient temperature

With n-butyllithium; diisobutylaluminum hydride; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; hexane; dichloromethane; benzene;
DOI:10.1016/S0040-4020(98)00889-8