(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

Base Information

Chemical Name:(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol
CAS No.:218434-99-2
Molecular Formula:C₄₇H₆₆O₅SSi₂
Molecular Weight:799.275
Hs Code.:

(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

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Chemical Property of (E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

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Technology Process of (E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

There total 5 articles about (E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133094-78-7
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

: 218434-99-2
(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Me₃Al / hexane; benzene / 1 h / Ambient temperature

2: CBr₄, PPh₃ / acetonitrile / 2 h / Ambient temperature

3: DBU / benzene / 48 h / Heating

4: 65 percent / di-isobutylaluminium hydride / hexane; CH₂Cl₂ / 2 h / -78 °C

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

With n-butyllithium; diisobutylaluminum hydride; carbon tetrabromide; trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 218434-97-0
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-N-methoxy-3,3,N-trimethyl-4-phenylsulfanyl-butyramide

: 218434-99-2
(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / di-isobutylaluminium hydride / hexane; CH₂Cl₂ / 2 h / -78 °C

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

With n-butyllithium; diisobutylaluminum hydride; In hexane; dichloromethane;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 218434-99-2
(E)-(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxy)-3-[2-(4-methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-en-4-ol

Guidance literature:: Multi-step reaction with 2 steps

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

With n-butyllithium;
DOI:10.1016/S0040-4020(98)00889-8