2-Pyrimidinecarboxylicacid,5-(aminomethyl)-(9CI)

Base Information

• Chemical Name: 2-Pyrimidinecarboxylicacid,5-(aminomethyl)-(9CI)
• CAS No.: 76196-72-0
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Hs Code.: 2933599090
• Mol file: 76196-72-0.mol

Synonyms:2-Pyrimidinecarboxylicacid,5-(aminomethyl)-(9CI);5-Aminomethyl-pyrimidine-2-carboxylic acid

Chemical Property of 2-Pyrimidinecarboxylicacid,5-(aminomethyl)-(9CI)

Chemical Property:

• PSA: 89.10000
• LogP: 0.33380

Purity/Quality:

99%min ^*data from raw suppliers

5-Aminomethyl-pyrimidine-2-carboxylicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinecarboxylicacid,5-(aminomethyl)-(9CI)

There total 4 articles about 2-Pyrimidinecarboxylicacid,5-(aminomethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

5-Phthalimidomethylpyrimidine-2-carboxylic acid (76196-70-8) → 5-Aminomethylpyrimidine-2-carboxylic acid (76196-72-0)

Guidance literature:

With hydrazine hydrate; In methanol; for 40h; Heating;

Reference yield:

Methyl 5-methylpyrimidine-2-carboxylate (76196-80-0) → 5-Aminomethylpyrimidine-2-carboxylic acid (76196-72-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 12 percent / NBS, benzoyl peroxide / benzene / 5 h / Heating

2: 64 percent / dimethylformamide / 4 h / 50 - 60 °C

3: 0.5 N NaOH / 1 h

4: 25 percent / 80 percent N₂H₄*H₂O / methanol / 40 h / Heating

With sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; hydrazine hydrate; In methanol; N,N-dimethyl-formamide; benzene;

Reference yield:

methyl 5-(bromomethyl)pyrimidine-2-carboxylate (76196-68-4) → 5-Aminomethylpyrimidine-2-carboxylic acid (76196-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / dimethylformamide / 4 h / 50 - 60 °C

2: 0.5 N NaOH / 1 h

3: 25 percent / 80 percent N₂H₄*H₂O / methanol / 40 h / Heating

With sodium hydroxide; hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

5-Phthalimidomethylpyrimidine-2-carboxylic acid

Methyl 5-methylpyrimidine-2-carboxylate

methyl 5-(bromomethyl)pyrimidine-2-carboxylate

Methyl 5-phthalimidomethylpyrimidine-2-carboxylate

Refernces