5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
CAS No.:1570494-48-2
Molecular Formula:C₁₉H₁₃BrF₃N₅O₂
Molecular Weight:480.244
Hs Code.:

Synonyms:5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Suppliers and Price of 5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:: 98%+ ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of 5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

There total 6 articles about 5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.9%

: 823-78-9
meta-bromobenzyl bromide

: 1570493-58-1
5-(5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

: 1570494-48-2
5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1038/s41591-018-0052-4

Reference yield:

: 883028-82-8
3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carbohydrazide

: 1570494-48-2
5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran / Reflux

2: ethylene glycol / 3 h / 180 °C

3: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 1258269-03-2
ethyl 3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole-5-carboxylate

: 1570494-48-2
5-(1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol

2: sodium hydroxide / tetrahydrofuran / Reflux

3: ethylene glycol / 3 h / 180 °C

4: potassium carbonate / N,N-dimethyl-formamide / 50 °C

With potassium carbonate; hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; ethanol; ethylene glycol; N,N-dimethyl-formamide;