(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Name:(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1474049-94-9
Molecular Formula:C₂₅H₁₇FN₄O₃
Molecular Weight:440.433
Hs Code.:

Synonyms:(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 10 articles about (Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1474049-93-8
1-(4-fluorophenyl)-2-oxo-N-(2-oxoindolin-4-yl)-1,2-dihydropyridine-3-carboxamide

: 1474049-94-9
(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With pyrrolidine; In ethanol; Reflux;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1474049-94-9
(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 6 h

1.2: 12 h

2.1: sodium hydroxide / methanol / 3 h / 65 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; acetonitrile / 14 h

4.1: pyrrolidine / ethanol / Reflux

With pyrrolidine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 868171-66-8
1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid methyl ester

: 1474049-94-9
(Z)-N-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-4-yl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 3 h / 65 °C

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; acetonitrile / 14 h

3: pyrrolidine / ethanol / Reflux

With pyrrolidine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;