2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate

Base Information

• Chemical Name: 2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate
• CAS No.: 1268821-74-4
• Molecular Formula: C₂₀H₁₅ClN₆O₄S
• Molecular Weight: 470.896
• Mol file: 1268821-74-4.mol

Synonyms:2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate

Chemical Property of 2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate

There total 4 articles about 2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-(furan-3-yl)-4-((3-chloro-4-hydroxy-benzyl)(4H-1,2,4-triazol-4-yl)amino)-benzonitrile (1268821-73-3) → 2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate (1268821-74-4)

Guidance literature:

With sulphamoyl chloride; In N,N-dimethyl acetamide; at 20 ℃; Cooling with ice bath;

Reference yield:

4-hydroxy-3-chlorobenzaldehyde (2420-16-8) → 2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate (1268821-74-4)

Guidance literature:

Multi-step reaction with 4 steps

1: Trimethyl borate; ethanol; sodium tetrahydroborate / tetrahydrofuran

2: thionyl chloride / dichloromethane / 0.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide

4: sulphamoyl chloride / N,N-dimethyl acetamide / 20 °C / Cooling with ice bath

With sodium tetrahydroborate; thionyl chloride; Trimethyl borate; ethanol; sulphamoyl chloride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

3-Chlor-4-hydroxybenzylchlorid (141805-79-0) → 2-chloro-4-(((3-(furan-3-yl)-4-cyano-phenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate (1268821-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: sulphamoyl chloride / N,N-dimethyl acetamide / 20 °C / Cooling with ice bath

With sulphamoyl chloride; potassium carbonate; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

upstream raw materials:

4-hydroxy-3-chlorobenzaldehyde

2-(furan-3-yl)-4-((3-chloro-4-hydroxy-benzyl)(4H-1,2,4-triazol-4-yl)amino)-benzonitrile

2-chloro-4-(hydroxymethyl)phenol

3-Chlor-4-hydroxybenzylchlorid