3-Chloro-4-hydroxybenzyl alchol

Base Information

• Chemical Name: 3-Chloro-4-hydroxybenzyl alchol
• CAS No.: 105960-29-0
• Molecular Formula: C7H7 Cl O2
• Molecular Weight: 158.584
• Mol file: 105960-29-0.mol

Synonyms:Benzylalcohol, 3-chloro-4-hydroxy- (4CI); 3-Chloro-4-hydroxybenzyl alcohol;4-(Hydroxymethyl)-2-chlorophenol; NSC 85481

Chemical Property of 3-Chloro-4-hydroxybenzyl alchol

Chemical Property:

• PSA: 40.46000
• LogP: 1.53790

Purity/Quality:

99% ^*data from raw suppliers

BENZENEMETHANOL,3-CHLORO-4-HYDROXY 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-4-hydroxybenzyl alchol

There total 9 articles about 3-Chloro-4-hydroxybenzyl alchol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 4-hydroxy-3-chlorobenzoate (3964-57-6) → 2-chloro-4-(hydroxymethyl)phenol (105960-29-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h;

DOI:10.1021/jm970589l

Reference yield: 80.0%

4-hydroxy-3-chlorobenzaldehyde (2420-16-8) → 2-chloro-4-(hydroxymethyl)phenol (105960-29-0)

Guidance literature:

4-hydroxy-3-chlorobenzaldehyde; With sodium tetrahydroborate; Trimethyl borate; ethanol; In tetrahydrofuran;

With water; In tetrahydrofuran; ethanol; ethyl acetate;

Reference yield: 42.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-monochlorophenol (95-57-8) → 2-chloro-4-(hydroxymethyl)phenol (105960-29-0)

Guidance literature:

With sodium metaborate tetrahydrate; In water; at 50 ℃;

DOI:10.1021/acs.orglett.9b02372

upstream raw materials:

formaldehyd

2-monochlorophenol

4-hydroxy-3-chlorobenzaldehyde

3-Chlor-4-hydroxybenzylchlorid

Downstream raw materials:

4-hydroxy-3-chlorobenzaldehyde

5-((3-chloro-4-hydroxybenzyl)(4H-1,2,4-triazol-4-yl)amino)biphenyl-2-carbonitrile

2-chloro-4-(((6-cyanobiphenyl-3-yl)(4H-1,2,4-triazol-4-yl)amino)methyl)-phenyl sulfamate

3-Chlor-4-hydroxybenzylchlorid

Refernces

• 1、 -. "PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS". . . Retrieved 2019/10/23.
• 2、 Matysiak, Stefan,Fitznar, Hans-Peter,Schnell, Ralf,Pfleiderer, Wolfgang. "Acetals as New 2′-O-Protecting Functions for the Synthesis of Oligoribonucleotides: Synthesis of Uridine Building Blocks and Evaluation of Their Relative Acid Stability". . p. 1545 - 1566. Retrieved 2007/10/03.