4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid

Base Information

Chemical Name:4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid
CAS No.:1232860-80-8
Molecular Formula:C₃₅H₃₂F₅NO₅
Molecular Weight:641.635
Hs Code.:

Synonyms:4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid

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Chemical Property of 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid

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Technology Process of 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid

There total 10 articles about 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232860-78-4
diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

: 1232860-80-8
4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid

Guidance literature:: diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate; With water; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; at 20 ℃; for 4h;

With hydrogenchloride; In 1,2-dimethoxyethane; ethanol; water; Cooling with ice;

Reference yield:

: 1232860-72-8
4-(pentafluorophenyl)but-3-yn-1-ol

: 1232860-80-8
4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 8 h / 20 °C / Inert atmosphere

2.1: trimethylamine hydrochloride; triethylamine / toluene / 22 h / 0 - 20 °C

2.2: 0.25 h

3.1: caesium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

4.1: sodium hydroxide; water / ethanol; 1,2-dimethoxyethane / 4 h / 20 °C

With palladium 10% on activated carbon; water; hydrogen; trimethylamine hydrochloride; caesium carbonate; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1232860-74-0
4-(pentafluorophenyl)butan-1-ol

: 1232860-80-8
4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylamine hydrochloride; triethylamine / toluene / 22 h / 0 - 20 °C

1.2: 0.25 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

3.1: sodium hydroxide; water / ethanol; 1,2-dimethoxyethane / 4 h / 20 °C

With water; trimethylamine hydrochloride; caesium carbonate; triethylamine; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;