diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

Base Information

Chemical Name:diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate
CAS No.:1232860-78-4
Molecular Formula:C₃₉H₄₀F₅NO₅
Molecular Weight:697.742
Hs Code.:

Synonyms:diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

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Chemical Property of diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

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Technology Process of diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

There total 8 articles about diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1232860-76-2
4-(pentafluorophenyl)butyl 4-methylbenzene sulfonate

: 1232860-70-6
diethyl 4,4′-{7-[(4-hydroxyphenyl)ethynyl]-2-methyl-1H-indole-1,3-diyl}dibutanoate

: 1232860-78-4
diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 10h;

Reference yield:

: 1232860-72-8
4-(pentafluorophenyl)but-3-yn-1-ol

: 1232860-78-4
diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 8 h / 20 °C / Inert atmosphere

2.1: trimethylamine hydrochloride; triethylamine / toluene / 22 h / 0 - 20 °C

2.2: 0.25 h

3.1: caesium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

With palladium 10% on activated carbon; hydrogen; trimethylamine hydrochloride; caesium carbonate; triethylamine; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 3128-07-2
6-oxoheptanoic acid

: 1232860-78-4
diethyl 4,4'-[2-methyl-7-({4-[4-(pentafluorophenyl)butoxy]phenyl}ethynyl)-1H-indole-1,3-diyl]dibutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 0.67 h / 50 °C

1.2: 16 h / Reflux

2.1: caesium carbonate / dimethyl sulfoxide / 16 h / 50 °C

3.1: diisopropylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / acetonitrile / 15 h / 20 °C / Inert atmosphere

4.1: potassium carbonate / ethanol; 1,2-dimethoxyethane / 15 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate; caesium carbonate; diisopropylamine; In 1,2-dimethoxyethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;