1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Base Information

Chemical Name:1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile
CAS No.:1315465-37-2
Molecular Formula:C₁₇H₁₂F₃N₅O
Molecular Weight:359.31
Hs Code.:

Synonyms:1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

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Chemical Property of 1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

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Technology Process of 1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

There total 5 articles about 1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315464-58-4
6-(4-(3-hydroxypropyl)-3-(trifluoromethyl)phenyl)-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

: 1315465-37-2
1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: With Dess-Martin periodane; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

: 944388-71-0
4-amino-6-chloro-3-nitropyridine-2-carbonitrile

: 1315465-37-2
1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 5 h / 80 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

3: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

4: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 12.03 h / 20 °C

5: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; potassium carbonate; Dess-Martin periodane; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1104380-98-4
6-chloro-4-(methylamino)-3-nitro-2-pyridinecarbonitrile

: 1315465-37-2
1-methyl-6-(4-(3-oxopropyl)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate / ethanol / 3 h / 20 °C

2: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

3: hydrogenchloride; sodium nitrite / 1-methyl-pyrrolidin-2-one; water / 12.03 h / 20 °C

4: Dess-Martin periodane / dichloromethane; dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; potassium phosphate; tin(II) chloride dihdyrate; Dess-Martin periodane; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;