8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane

Base Information

Chemical Name:8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane
CAS No.:138154-97-9
Molecular Formula:C₂₀H₂₆Cl₂N₂O₃
Molecular Weight:413.344
Hs Code.:

Synonyms:8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane

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Chemical Property of 8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane

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Technology Process of 8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane

There total 7 articles about 8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125104-19-0
(±)-methyl 1-benzyloxycarbonyl-4-oxopiperidine-2-carboxylate

: 138154-97-9
8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / PTSA, 4 Angstroem molecular sieves / benzene / 4 h / Heating

2: 91 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

3: 79 percent / 2 h / 150 °C

4: 43 percent / LiAlH₄ / tetrahydrofuran / 19 h / Heating

5: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 1 h, 2.) acetonitrile, RT, 4 h

With lithium aluminium tetrahydride; 4 A molecular sieve; hydrogen; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm00081a009

Reference yield:

: 125104-17-8
2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

: 138154-97-9
8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Me₂PhSiH, (Ph₃P)3RhCl, 2.) 40percent aq. HF / 1.) 50 deg C, 3 h, 2.) acetonitrile, RT, 18 h

2: 99 percent / PTSA, 4 Angstroem molecular sieves / benzene / 4 h / Heating

3: 91 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

4: 79 percent / 2 h / 150 °C

5: 43 percent / LiAlH₄ / tetrahydrofuran / 19 h / Heating

6: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 1 h, 2.) acetonitrile, RT, 4 h

With Wilkinson's catalyst; lithium aluminium tetrahydride; 4 A molecular sieve; Dimethylphenylsilane; hydrogen fluoride; hydrogen; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm00081a009

Reference yield:

: 125104-21-4
7-methyl 8-(phenylmethyl) 1,4-dioxa-8-azaspiro<4.5>decane-7,8-dicarboxylate

: 138154-97-9
8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dioxa-8-azaspiro<4.5>decane

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

2: 79 percent / 2 h / 150 °C

3: 43 percent / LiAlH₄ / tetrahydrofuran / 19 h / Heating

4: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 1 h, 2.) acetonitrile, RT, 4 h

With lithium aluminium tetrahydride; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm00081a009