(R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

Base Information

Chemical Name:(R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide
CAS No.:1351186-39-4
Molecular Formula:C₂₉H₄₅NO₂Si
Molecular Weight:467.767
Hs Code.:

Synonyms:(R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

Suppliers and Price of (R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

Chemical Property:

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Technology Process of (R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

There total 8 articles about (R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1351186-32-7
(R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-2-methylbutanamide

: 74-88-4
methyl iodide

: 1351186-39-4
(R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo201951s

Reference yield:

: C₂₄H₃₄O₃Si

: 1351186-39-4
(R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

Guidance literature:: Multi-step reaction with 6 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 0.25 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 15 h / 20 - 40 °C

4: water; triphenylphosphine / tetrahydrofuran / 12 h / 20 - 40 °C

5: diethyl cyanophosphonate; triethylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

6: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium azide; diethyl cyanophosphonate; water; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; 4: Staudinger reaction;
DOI:10.1021/jo201951s

Reference yield:

: 1351186-28-1
(S,E)-methyl 6-(tert-butyldiphenylsilyloxy)-5-methylhex-2-enoate

: 1351186-39-4
(R)-N-((S)-6-(tert-butyldiphenylsilyloxy)-5-methylhexyl)-N,2-dimethylbutanamide

Guidance literature:: Multi-step reaction with 7 steps

1: palladium on activated charcoal; hydrogen / ethyl acetate / 17 h / 20 °C

2: diisobutylaluminium hydride / dichloromethane; toluene / 0.25 h / 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 15 h / 20 - 40 °C

5: water; triphenylphosphine / tetrahydrofuran / 12 h / 20 - 40 °C

6: diethyl cyanophosphonate; triethylamine / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

7: n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium azide; diethyl cyanophosphonate; palladium on activated charcoal; water; hydrogen; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 5: Staudinger reaction;
DOI:10.1021/jo201951s