1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate

Base Information

Chemical Name:1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate
CAS No.:152775-52-5
Molecular Formula:C₂₃H₃₁N₅O₄
Molecular Weight:441.53
Hs Code.:

Synonyms:1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate

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Chemical Property of 1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate

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Technology Process of 1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate

There total 10 articles about 1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 152775-52-5
1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

2: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

3: 86.2 percent / LAH / tetrahydrofuran / 0.5 h / Ambient temperature

4: 92.2 percent / Br₂, Ph₃P / CH₂Cl₂ / 0.17 h

5: 1.) N-isopropylcyclohexylamine, n-butyllithium / 1.) THF, hexane, 30 min, 2.) THF, hexane, DMSO, RT, 1 h

With lithium aluminium tetrahydride; n-butyllithium; N-cyclohexylisopropylamine; bromine; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jm00074a004

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 152775-52-5
1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate

Guidance literature:: Multi-step reaction with 9 steps

1: 93.2 percent / K₂CO₃ / acetone / 18 h / Heating

2: 62 percent / NaN₃, NH₄Cl / dimethylformamide / 24 h / 110 °C

3: 67 percent / K₂CO₃ / acetonitrile / 1 h / Heating

4: 96 percent / BBr₃ / CH₂Cl₂

5: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

6: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

7: 86.2 percent / LAH / tetrahydrofuran / 0.5 h / Ambient temperature

8: 92.2 percent / Br₂, Ph₃P / CH₂Cl₂ / 0.17 h

9: 1.) N-isopropylcyclohexylamine, n-butyllithium / 1.) THF, hexane, 30 min, 2.) THF, hexane, DMSO, RT, 1 h

With lithium aluminium tetrahydride; n-butyllithium; sodium azide; N-cyclohexylisopropylamine; bromine; boron tribromide; potassium carbonate; ammonium chloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00074a004

Reference yield:

: 152775-45-6
4-methoxy-3,5-dimethylbenzonitrile

: 152775-52-5
1,1-dimethylethyl 5-<3-<2,6-dimethyl-4-<5-(2-methyl-2H-tetrazolyl)>phenoxy>propyl>-3-isoxazolepropanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 62 percent / NaN₃, NH₄Cl / dimethylformamide / 24 h / 110 °C

2: 67 percent / K₂CO₃ / acetonitrile / 1 h / Heating

3: 96 percent / BBr₃ / CH₂Cl₂

4: 84 percent / Ph₃P, DEAD / CH₂Cl₂ / 12 h

5: 37.5 percent / triethylamine / CHCl₃ / 18 h / Heating

6: 86.2 percent / LAH / tetrahydrofuran / 0.5 h / Ambient temperature

7: 92.2 percent / Br₂, Ph₃P / CH₂Cl₂ / 0.17 h

8: 1.) N-isopropylcyclohexylamine, n-butyllithium / 1.) THF, hexane, 30 min, 2.) THF, hexane, DMSO, RT, 1 h

With lithium aluminium tetrahydride; n-butyllithium; sodium azide; N-cyclohexylisopropylamine; bromine; boron tribromide; potassium carbonate; ammonium chloride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00074a004