1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine

Base Information

Chemical Name:1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine
CAS No.:865996-27-6
Molecular Formula:C₁₉H₂₉NO₃Si
Molecular Weight:347.53
Hs Code.:

Synonyms:1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine

Chemical Property:

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Technology Process of 1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine

There total 4 articles about 1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865996-28-7
4-hydroxy-3,4-dihydropyridine-1(2H)-carboxylic acid benzyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 865996-27-6
1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 23 ℃;
DOI:10.1021/jo051117e

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 865996-27-6
1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium borohydride / methanol; diethyl ether / 1 h / -78 °C

1.2: 80 percent / water / methanol; diethyl ether / -60 - 23 °C

2.1: cerium(III) chloride heptahydrate; sodium borohydride / methanol / 0 - 23 °C

3.1: 3.5 g / imidazole / dimethylformamide / 0 - 23 °C

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; In methanol; diethyl ether; N,N-dimethyl-formamide; 2.1: Luche reduction;
DOI:10.1021/jo051117e

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 865996-27-6
1-N-(benzyloxycarbonyl)-4-(tert-butyldimethylsilyloxy)-1,4,5,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium borohydride / methanol; diethyl ether / 1 h / -78 °C

1.2: 80 percent / water / methanol; diethyl ether / -60 - 23 °C

2.1: cerium(III) chloride heptahydrate; sodium borohydride / methanol / 0 - 23 °C

3.1: 3.5 g / imidazole / dimethylformamide / 0 - 23 °C

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; In methanol; diethyl ether; N,N-dimethyl-formamide; 2.1: Luche reduction;
DOI:10.1021/jo051117e