3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

Base Information

Chemical Name:3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether
CAS No.:541541-08-6
Molecular Formula:C₃₅H₅₀O₆SSi
Molecular Weight:626.93
Hs Code.:

Synonyms:3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

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Chemical Property of 3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

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Technology Process of 3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

There total 8 articles about 3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 541541-05-3
3-[(2-hydroxy-2-methylpropyl)sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

: 541541-08-6
3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 541541-08-6
3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 °C

1.2: 81 percent / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: acetyl chloride / 1 h / Heating

3.1: 43.2 g / pyridine / 0 °C

4.1: 77 percent Spectr_. / N-bromosuccinimide; N,N'-azobisisobutyronitrile / CCl₄ / 0.33 h / Heating

5.1: 32 g / N-ethyldiisopropylamine / dimethylformamide / 3 h / 20 °C

6.1: 74 percent / m-chloroperbenzoic acid; sodium bicarbonate / CH₂Cl₂ / 0.17 h / 0 °C

7.1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; magnesium; N-ethyl-N,N-diisopropylamine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 99-36-5
1-methoxycarbonyl-3-methylbenzene

: 541541-08-6
3-[[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl]-4',4''-dimethoxytrityl 1-methylethyl ether

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 °C

1.2: 81 percent / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: acetyl chloride / 1 h / Heating

3.1: 43.2 g / pyridine / 0 °C

4.1: 77 percent Spectr_. / N-bromosuccinimide; N,N'-azobisisobutyronitrile / CCl₄ / 0.33 h / Heating

5.1: 32 g / N-ethyldiisopropylamine / dimethylformamide / 3 h / 20 °C

6.1: 74 percent / m-chloroperbenzoic acid; sodium bicarbonate / CH₂Cl₂ / 0.17 h / 0 °C

7.1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; magnesium; N-ethyl-N,N-diisopropylamine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;