(E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate

Base Information

Chemical Name:(E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate
CAS No.:1455451-89-4
Molecular Formula:C₂₄H₂₇NO₇
Molecular Weight:441.481
Hs Code.:

Synonyms:(E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate

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Chemical Property of (E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate

Chemical Property:

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Technology Process of (E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate

There total 4 articles about (E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13433-00-6
diethyl aminomalonate hydrochloride

: 126266-12-4
2-(2-formyl-4,5-(methylenedioxy)phenyl)ethyl benzyl ether

: 1455451-89-4
(E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate

Guidance literature:: With sodium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1016/j.tet.2013.08.012

Reference yield:

: 5-(2-benzyloxyethyl)-6-bromo-1,3-benzodioxole

: 1455451-89-4
(E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 °C / Inert atmosphere

2.1: sodium sulfate; triethylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium sulfate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2013.08.012

Reference yield:

: 119054-94-3
2-(2'-bromo-4',5'-methylenedioxyphenyl)ethanol

: 1455451-89-4
(E)-diethyl N-[2-(2-benzyloxyethyl)-4,5-methylenedioxybenzylideneamino]malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 6 h / -78 °C / Inert atmosphere

3.1: sodium sulfate; triethylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

With n-butyllithium; sodium sulfate; triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2013.08.012