{1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester
• CAS No.: 119805-70-8
• Molecular Formula: C₃₁H₃₁N₇O₃
• Molecular Weight: 549.632

Synonyms:{1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Chemical Property of {1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

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Technology Process of {1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

There total 2 articles about {1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl-[9-(2-nitro-benzyl)-9H-purin-6-yl]-amine (10549-98-1) → {1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester (119805-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / H₂ / 10percent Pd/C / acetic acid / 1.5 h / 1520 - 2280 Torr

2: 1.) triethylamine, ethyl chloroformate / 1.) THF, 10 min; 2.) THF, acetic acid, r.t., 15 h

With hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In acetic acid;

DOI:10.1016/0223-5234(88)90202-4

Reference yield:

Z-DL-Phe-OH (3588-57-6) + 6-(Dimethylamino)-9-(2-aminobenzyl)-9H-purine (112089-26-6) → {1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester (119805-70-8)

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.) THF, 10 min; 2.) THF, acetic acid, r.t., 15 h;

DOI:10.1016/0223-5234(88)90202-4

Reference yield:

{1-[2-(6-Dimethylamino-purin-9-ylmethyl)-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester (119805-70-8) → 2-Amino-N-[2-(6-dimethylamino-purin-9-ylmethyl)-phenyl]-3-phenyl-propionamide (119805-76-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; acetic acid; under 1520 - 2280 Torr;

DOI:10.1016/0223-5234(88)90202-4

upstream raw materials:

Z-DL-Phe-OH

6-(Dimethylamino)-9-(2-aminobenzyl)-9H-purine

dimethyl-[9-(2-nitro-benzyl)-9H-purin-6-yl]-amine

Downstream raw materials:

2-Amino-N-[2-(6-dimethylamino-purin-9-ylmethyl)-phenyl]-3-phenyl-propionamide

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