1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea

Base Information

• Chemical Name: 1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea
• CAS No.: 860994-76-9
• Molecular Formula: C₁₇H₃₄N₄OS
• Molecular Weight: 342.549

Synonyms:1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea

Chemical Property of 1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea

Chemical Property:

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Technology Process of 1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea

There total 3 articles about 1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(1R,2R)-N,N-dimethylcyclohexane-1,2-diamine (320778-92-5) + (S)-2-isothiocyanato-N,N,3,3-tetramethylbutanamide (764650-93-3) → 1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea (860994-76-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1002/chem.201405730

Reference yield:

C2H4O2*C17H34N4OS → 1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea (860994-76-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 23 ℃; pH=> 12;

DOI:10.1016/j.tetasy.2008.09.030

Reference yield:

C8H18N2O*C2HF3O2 → 1-{(S)-1-(dimethylcarbamoyl)-2,2-dimethylpropyl}-3-{(1R,2R)-2-(dimethylamino)cyclohexyl}thiourea (860994-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / dichloromethane

1.2: 2 h / 0 °C

2.1: dichloromethane / 48 h / 20 °C / Inert atmosphere

With sodium hydroxide; In dichloromethane;

DOI:10.1002/chem.201405730

upstream raw materials:

(1R,2R)-N,N-dimethylcyclohexane-1,2-diamine

(S)-2-isothiocyanato-N,N,3,3-tetramethylbutanamide

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