N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Base Information

Chemical Name:N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
CAS No.:958488-80-7
Molecular Formula:C₂₇H₃₃N₃O₆
Molecular Weight:495.576
Hs Code.:

Synonyms:N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

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Chemical Property of N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

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Technology Process of N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

There total 3 articles about N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958075-48-4
(3R,4R,5S)-4-hydroxy-5-((2E)-(1R)-1-hydroxy-4,4-dimethylpent-2-enyl)-3-methoxydihydrofuran-2-one

: 103343-47-1
3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

: 958488-80-7
N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Guidance literature:: With sodium 2-ethylhexanoic acid; In tetrahydrofuran; at 20 - 60 ℃; for 29h;

Reference yield:

: 108895-98-3
benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

: 958488-80-7
N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: formic acid / palladium 10% on activated carbon / methanol / 6 h / 50 °C

1.2: pH 8

2.1: sodium 2-ethylhexanoic acid / tetrahydrofuran / 29 h / 20 - 60 °C

With formic acid; sodium 2-ethylhexanoic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield:

: 270902-67-5
8,8-dimethyl-2-O-methyl-3,5-O-(1-methylethylidene)-6,7,8,9-tetradeoxy-D-gluo-6-nonenonic acid (6E)-γ-lactone

: 958488-80-7
N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / water / 1.5 h / 20 °C

2: sodium 2-ethylhexanoic acid / tetrahydrofuran / 29 h / 20 - 60 °C

With trifluoroacetic acid; sodium 2-ethylhexanoic acid; In tetrahydrofuran; water;