Technology Process of (E)-1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl acrylate
There total 4 articles about (E)-1-(2,4,5-trimethoxyphenyl)hexa-1,5-dien-3-yl acrylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.03.059
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
With
triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2012.03.059
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3.5 h / 80 °C / Air atmosphere
4.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C / Inert atmosphere
4.2: -78 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
With
sodium hydride; diisobutylaluminium hydride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.03.059
