[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

Base Information

Chemical Name:[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile
CAS No.:98634-61-8
Molecular Formula:C₁₉H₁₇F₂N₃
Molecular Weight:325.361
Hs Code.:

Synonyms:[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

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Chemical Property of [(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

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Technology Process of [(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

There total 1 articles about [(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 107-14-2
chloroacetonitrile

: 69623-07-0
(+/-)-4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2,3,4,4a,5,9a-hexahydro-1H-pyrido<4,3-b>indole

: 98634-61-8
[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

Guidance literature:: With sodium carbonate; potassium iodide; In various solvent(s); 1.) from 80 deg C to 90 deg C, 18 h, 2.) from 120 deg C to 130 deg C, 72 h;
DOI:10.1021/jm00151a002

Reference yield:

: 98634-61-8
[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

: 98651-81-1
2-[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-ethylamine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 1.5h;
DOI:10.1021/jm00151a002

Reference yield:

: 98634-61-8
[(4aR,9bR)-8-Fluoro-5-(4-fluoro-phenyl)-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indol-2-yl]-acetonitrile

: 98651-77-5
4a,9b-trans-8-fluoro-5-(4-fluorophenyl)-2-<2-(3-hydroxy-2-phenylpropionamido)ethyl>-1,2,3,4,4a,9b-trans-hexahydro-γ-carboline

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 1.5 h

2: 60 percent / 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

With lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane;
DOI:10.1021/jm00151a002