6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline

Base Information

Chemical Name:6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline
CAS No.:106635-82-9
Molecular Formula:C₂₆H₁₇F₃N₂O₄
Molecular Weight:478.427
Hs Code.:

Synonyms:6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline

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Chemical Property of 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline

Chemical Property:

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Technology Process of 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline

There total 1 articles about 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 85-44-9
phthalic anhydride

: 82333-41-3
8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline

: 106635-82-9
6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline

Guidance literature:: In xylene; for 24h; Heating;
DOI:10.1021/jm00128a010

Reference yield: 63.0%

: 106635-82-9
6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline

: 106635-83-0
6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 41h; Ambient temperature;
DOI:10.1021/jm00128a010

Reference yield:

: 106635-82-9
6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline

: 8-(4-Amino-1-methyl-butylamino)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 63 percent / 100percent m-chloroperbenzoic acid / CHCl₃ / 41 h / Ambient temperature

2: 75 percent / POCl₃ / CHCl₃ / 2 h / Heating

3: 89 percent / N₂H₄*H₂O / ethanol; H₂O / 3 h / Heating

4: 67 percent / NaH / dimethylformamide; paraffin

5: 77 percent / diisopropylamine / acetonitrile / Heating

6: hydrazine hydrate / ethanol; H₂O / Heating

7: 94 percent / H₂ / palladium black / acetic acid; aq. ethanol / 48 h / 2327.2 Torr

With hydrogen; sodium hydride; hydrazine hydrate; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; palladium; In ethanol; chloroform; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; paraffin;
DOI:10.1021/jm00128a010