106635-83-0

Basic information

• Product Name: 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 1-oxide
• Synonyms: 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 1-oxide
• CAS NO: 106635-83-0
• Molecular Weight: 494.427
• Mol File: 106635-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 1-oxide(106635-83-0)
• EPA Substance Registry System: 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 1-oxide(106635-83-0)

Safety Data

• Hazardous Substances Data: 106635-83-0(Hazardous Substances Data)

Upstream product

• 82333-41-3 8-amino-6-methoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline 
• 106635-82-9 6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 85-44-9 phthalic anhydride 

Downstream Products

• 106635-84-1 2-chloro-6-methoxy-4-methyl-8-phthalimido-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 106635-92-1 N⁴-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-yl]-pentane-1,4-diamine 
• 106635-80-7 tafenoquine 
• 121963-34-6 2-{4-[2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamino]-pentyl}-isoindole-1,3-dione 
• 106635-87-4 2,6-dimethoxy-4-methyl-8-<(4-phthalimido-1-methylbutyl)amino>-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 121963-32-4 2-(4-Chloro-benzyloxy)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-quinolin-8-ylamine 
• 106635-86-3 8-amino-2,6-dimethoxy-4-methyl-5-<3-(trifluoromethyl)phenoxy>quinoline 
• 106635-85-2 8-amino-2-chloro-6-methoxy-4-methyl-5-<3-(trifluoromethyl)phenoxy>quinoline 

Relevant articles and documents

Antimalarials. 16. Synthesis of 2-substituted analogues of 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl)phenoxy]quinoline as candidate antimalarials

A series of 2-substituted analogues of the exceptional drug 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3- (trifluoromethyl)phenoxy]quinoline (I) were prepared and evaluated for both suppressive and prophylactic antimalarial activity. The preparation of analogues of compound I was of interest due to the high level of both blood and tissue schizonticidal activity demonstrated by this compound. One analogue, 8a, was found to be both more active and less toxic than the parent compound I. In addition, three analogues of example 8a were prepared. Although two of the three analogues showed significant antimalarial activity, both were inferior to compound 8a.