N-[1-[2-(4-HYDROXY-PHENYL)-ETHYL]-PIPERIDIN-4-YL]-N-PHENYL-PROPIONAMIDE

Base Information

• Chemical Name: N-[1-[2-(4-HYDROXY-PHENYL)-ETHYL]-PIPERIDIN-4-YL]-N-PHENYL-PROPIONAMIDE
• CAS No.: 76107-53-4
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.477
• Hs Code.: 2933399090
• Mol file: 76107-53-4.mol

Synonyms:N-[1-[2-(4-HYDROXY-PHENYL)-ETHYL]-PIPERIDIN-4-YL]-N-PHENYL-PROPIONAMIDE;N-{1-[2-(4-Hydroxy-phenyl)-ethyl]-piperidin-4-yl}-

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Chemical Property of N-[1-[2-(4-HYDROXY-PHENYL)-ETHYL]-PIPERIDIN-4-YL]-N-PHENYL-PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 4.24E-11mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 511.9°C at 760 mmHg
• Flash Point: 263.4°C
• PSA: 43.78000
• Density: 1.145g/cm³
• LogP: 3.78020

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[1-[2-(4-HYDROXY-PHENYL)-ETHYL]-PIPERIDIN-4-YL]-N-PHENYL-PROPIONAMIDE

There total 7 articles about N-[1-[2-(4-HYDROXY-PHENYL)-ETHYL]-PIPERIDIN-4-YL]-N-PHENYL-PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(p-benzyloxyphenethyl)-4-(N-propionylanilino)piperidine → N-phenyl-N-[1-[2-(4-hydroxyphenyl)ethyl]-4-piperidinyl]propanamide (76107-53-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1248/cpb.33.3922

Reference yield:

2-(4-benzyloxyphenyl)ethanol (61439-59-6) → N-phenyl-N-[1-[2-(4-hydroxyphenyl)ethyl]-4-piperidinyl]propanamide (76107-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / CHCl₃ / 3 h / Heating

2: 0.9 g / KI, Na₂CO₃ / various solvent(s) / 48 h / Heating

3: 0.4 g / H₂ / 5percent Pd-C / ethanol

With thionyl chloride; hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; chloroform;

DOI:10.1248/cpb.33.3922

Reference yield:

4-(4-hydroxyphenyl)butanoic acid (7021-11-6) → N-phenyl-N-[1-[2-(4-hydroxyphenyl)ethyl]-4-piperidinyl]propanamide (76107-53-4)

Guidance literature:

Multi-step reaction with 4 steps

2: thionyl chloride / CHCl₃ / 3 h / Heating

3: 0.9 g / KI, Na₂CO₃ / various solvent(s) / 48 h / Heating

4: 0.4 g / H₂ / 5percent Pd-C / ethanol

With thionyl chloride; hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; chloroform;

DOI:10.1248/cpb.33.3922

upstream raw materials:

N-{1-[2-(4-Methoxy-phenyl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide

Norfentanyl

1-(2-Chloroethyl)-4-methoxybenzene

2-(4-benzyloxyphenyl)ethanol